Rarely, a lamia of great divine power undergoes an unholy and dramatic transformation, increasing in size and speed to become a truly intimidating foe. Manipulators and slavers, spiritual leaders and oppressive tyrants, lamia harridans are megalomaniacal, corrupt, and brutal.

The Harridan Template appeared in Appendix Six: Bestiary, page 404 of the Rise of the Runelords Anniversary Edition. It can be placed upon a Large size class lamia or lamia matriarch that has at least 10 levels in a Divine spellcasting class, though the template does not mesh perfectly with the lamia matriarch's abilities.

For the lamyros known as a Lamia Harridan, which first appeared in Spires of Xin-Shalast in the original Rise of the Runelords adventure path, see the Harridan page.